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DTSTART;TZID=America/New_York:20260203T110000
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DTSTAMP:20260404T040128
CREATED:20250812T203701Z
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UID:2251-1770116400-1770119400@inside.wooster.edu
SUMMARY:Chemistry and BCMB Seminar
DESCRIPTION:Sara E. S. Martin\, PhD\, Associate Professor\, Chemistry; Biochemistry & Molecular Biology\, The College of Wooster\n\n\n\n“Molecular Makeovers: From Simple Precursors to Bio‑Relevant Heterocycles”\n\n\n\n\n\n\n\nQuinolinones and coumarins are related nitrogen- and oxygen-containing heterocycles that appear in a variety of bioactive molecules\, including pH probes\, natural products\, and pharmaceuticals. Despite their importance\, certain isomers of these molecules are hard to make. Most current synthetic routes to access 7-substituted quinolinones and coumarins either work for only a narrow set of starting materials or require multiple steps that change oxidation states after the molecule’s carbon framework is already built. These approaches limit how easily chemists can explore new structures. \n\n\n\nResearch in the Martin lab has taken a different strategy to build quinolinones\, forming the carbon skeleton from simpler building blocks using a two-step reaction sequence that converts meta‑substituted anilines and methyl 3\,3‑dimethoxypropionate to mainly 7‑substituted quinolinones. This seminar will discuss recently published studies aimed at understanding what controls the ratio of the two isomeric products and more recent work aimed at 1) developing milder reaction conditions for this transformation  2) synthesizing interesting biologically relevant quinonliones\, and 3) optimizing reaction conditions for coumarin synthesis. \n\n\n\n\n\nLocation: Ruth W. Williams Hall of Life Sciences\, Room 060
URL:https://inside.wooster.edu/chemistry/event/chemistry-and-bcmb-seminar/
CATEGORIES:BCMB,Chemistry,Seminars,Seniors,STEM Success Initiative
ATTACH;FMTTYPE=image/jpeg:https://inside.wooster.edu/chemistry/wp-content/uploads/sites/59/2025/08/Group-photo-scaled.jpg
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DTSTART;TZID=America/New_York:20260210T110000
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CREATED:20250812T145609Z
LAST-MODIFIED:20250812T150032Z
UID:2229-1770721200-1770724200@inside.wooster.edu
SUMMARY:Chemistry Seminar
DESCRIPTION:Casey Wade\, Associate Professor\, The Ohio State University\n\n\n\nLocation: Ruth W. Williams Hall of Life Sciences\, Room 045
URL:https://inside.wooster.edu/chemistry/event/chemistry-seminar-4/
CATEGORIES:Chemistry,Seminars,Seniors,STEM Success Initiative
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