{"id":2251,"date":"2025-08-12T16:37:01","date_gmt":"2025-08-12T20:37:01","guid":{"rendered":"https:\/\/inside.wooster.edu\/chemistry\/?post_type=tribe_events&#038;p=2251"},"modified":"2026-01-22T17:06:56","modified_gmt":"2026-01-22T22:06:56","slug":"chemistry-and-bcmb-seminar","status":"publish","type":"tribe_events","link":"https:\/\/inside.wooster.edu\/chemistry\/event\/chemistry-and-bcmb-seminar\/","title":{"rendered":"Chemistry and BCMB Seminar"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Sara E. S. Martin, PhD, Associate Professor, Chemistry; Biochemistry &amp; Molecular Biology, The College of Wooster<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">\u201cMolecular Makeovers: From\u00a0Simple\u00a0Precursors to Bio\u2011Relevant Heterocycles\u201d<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"622\" height=\"1024\" src=\"https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-622x1024.png\" alt=\"\" class=\"wp-image-2461\" style=\"width:453px;height:auto\" srcset=\"https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-622x1024.png 622w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-182x300.png 182w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-768x1265.png 768w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-933x1536.png 933w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2025\/08\/Martin-Seminar-2026-1243x2048.png 1243w\" sizes=\"auto, (max-width: 622px) 100vw, 622px\" \/><\/figure>\n<\/div>\n\n\n<p>Quinolinones and coumarins are related nitrogen- and oxygen-containing heterocycles that appear in a variety of bioactive molecules, including pH probes, natural products, and pharmaceuticals. Despite their importance, certain isomers of these molecules are hard to make. Most current synthetic routes to access 7-substituted quinolinones and coumarins either work for only a narrow set of starting materials or require multiple steps that change oxidation states after the molecule\u2019s carbon framework is already built. These approaches limit how easily chemists can explore new structures.<\/p>\n\n\n\n<p>Research in the Martin lab has taken a different strategy to build quinolinones, forming the carbon skeleton from simpler building blocks using a two-step reaction sequence that converts meta\u2011substituted anilines and methyl 3,3\u2011dimethoxypropionate to mainly 7\u2011substituted quinolinones. This seminar will discuss recently published studies aimed at understanding what controls the ratio of the two isomeric products and more recent work aimed at 1) developing milder reaction conditions for this transformation &nbsp;2) synthesizing interesting biologically relevant quinonliones, and 3)&nbsp;optimizing&nbsp;reaction conditions for&nbsp;coumarin synthesis.<\/p>\n\n\n<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<p class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\tFebruary 3\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t@\t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t11:00 am\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--time\">\n\t\t\t\t\t&#8211;\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--end\">\n\t\t\t\t\t11:50 am\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__timezone\">EST<\/span>\n\t\t\t\t\t\t<\/p>\n<\/div>\n\n\n\n<p>Location: Ruth W. Williams Hall of Life Sciences, Room 060<\/p>\n\n\n<div  class=\"tribe-block tribe-block__event-price\" >\n\t\t<\/div>\n\n\n\n\n<div  class=\"tribe-block tribe-block__venue tribe-clearfix\" >\n\t\n\t\t\n\t<\/div>\n\n\n\n\n\t<div  class=\"tribe-block tribe-block__events-link\" >\n\t\t<div class=\"tribe-events tribe-common\">\n\t\t\t<div class=\"tribe-events-c-subscribe-dropdown__container\">\n\t\t\t\t<div class=\"tribe-events-c-subscribe-dropdown\">\n\t\t\t\t\t<div class=\"tribe-common-c-btn-border tribe-events-c-subscribe-dropdown__button\">\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--cal-export tribe-events-c-subscribe-dropdown__export-icon\" \taria-hidden=\"true\"\n\tviewBox=\"0 0 23 17\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M.128.896V16.13c0 .211.145.383.323.383h15.354c.179 0 .323-.172.323-.383V.896c0-.212-.144-.383-.323-.383H.451C.273.513.128.684.128.896Zm16 6.742h-.901V4.679H1.009v10.729h14.218v-3.336h.901V7.638ZM1.01 1.614h14.218v2.058H1.009V1.614Z\" \/>\n\t<path d=\"M20.5 9.846H8.312M18.524 6.953l2.89 2.909-2.855 2.855\" stroke-width=\"1.2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n<\/svg>\n\t\t\t\t\t\t<button\n\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__button-text\"\n\t\t\t\t\t\t\taria-expanded=\"false\"\n\t\t\t\t\t\t\taria-controls=\"tribe-events-subscribe-dropdown-content\"\n\t\t\t\t\t\t\taria-label=\"View links to add events to your calendar\"\n\t\t\t\t\t\t>\n\t\t\t\t\t\t\tAdd to calendar\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--caret-down tribe-events-c-subscribe-dropdown__button-icon\" \taria-hidden=\"true\"\n\tviewBox=\"0 0 10 7\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M1.008.609L5 4.6 8.992.61l.958.958L5 6.517.05 1.566l.958-.958z\" class=\"tribe-common-c-svgicon__svg-fill\"\/>\n<\/svg>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"tribe-events-subscribe-dropdown-content\" class=\"tribe-events-c-subscribe-dropdown__content\">\n\t\t\t\t\t\t<ul class=\"tribe-events-c-subscribe-dropdown__list\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--gcal\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"https:\/\/www.google.com\/calendar\/event?action=TEMPLATE&#038;dates=20260203T110000\/20260203T115000&#038;text=Chemistry%20and%20BCMB%20Seminar&#038;details=%3Ch2+class%3D%22wp-block-heading%22%3ESara+E.+S.+Martin%2C+PhD%2C+Associate+Professor%2C+Chemistry%3B+Biochemistry+%26amp%3B+Molecular+Biology%2C+The+College+of+Wooster%3C%2Fh2%3E%3Ch2+class%3D%22wp-block-heading%22%3E%E2%80%9CMolecular+Makeovers%3A+From%C2%A0Simple%C2%A0Precursors+to+Bio%E2%80%91Relevant+Heterocycles%E2%80%9D%3C%2Fh2%3E%3Cfigure+class%3D%22wp-block-image+alignright+size-large+is-resized%22%3E%3Cimg+src%3D%22https%3A%2F%2Finside.wooster.edu%2Fchemistry%2Fwp-content%2Fuploads%2Fsites%2F59%2F2025%2F08%2FMartin-Seminar-2026-622x1024.png%22+alt%3D%22%22+class%3D%22wp-image-2461%22+style%3D%22width%3A453px%3Bheight%3Aauto%22+%2F%3E%3C%2Ffigure%3E%3Cp%3EQuinolinones+and+coumarins+are+related+nitrogen-+and+oxygen-containing+heterocycles+that+appear+in+a+variety+of+bioactive+molecules%2C+including+pH+probes%2C+natural+products%2C+and+pharmaceuticals.+Despite+their+importance%2C+certain+isomers+of+these+molecules+are+hard+to+make.+Most+current+synthetic+routes+to+access+7-substituted+quinolinones+and+coumarins+either+work+for+only+a+narrow+set+of+starting+materials+or+require+multiple+steps+that+change+oxidation+stat%3C%2Fp%3E+%28View+Full+event+Description+Here%3A+https%3A%2F%2Finside.wooster.edu%2Fchemistry%2Fevent%2Fchemistry-and-bcmb-seminar%2F%29&#038;trp=false&#038;ctz=America\/New_York&#038;sprop=website:https:\/\/inside.wooster.edu\/chemistry\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tGoogle Calendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--ical\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tiCalendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-365\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook 365\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-live\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook Live\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Sara E. S. Martin, PhD, Associate Professor, Chemistry; Biochemistry &amp; Molecular Biology, The College of Wooster \u201cMolecular Makeovers: From\u00a0Simple\u00a0Precursors to Bio\u2011Relevant Heterocycles\u201d Quinolinones and coumarins are related nitrogen- and oxygen-containing [&hellip;]<\/p>\n","protected":false},"author":95,"featured_media":2458,"template":"","meta":{"_EventAllDay":false,"_EventTimezone":"America\/New_York","_EventStartDate":"2026-02-03 11:00:00","_EventEndDate":"2026-02-03 11:50:00","_EventStartDateUTC":"2026-02-03 16:00:00","_EventEndDateUTC":"2026-02-03 16:50:00","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"$","_EventCurrencyCode":"USD","_EventCurrencyPosition":"prefix","_EventDateTimeSeparator":"@","_EventTimeRangeSeparator":"-","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[29,28,10],"tribe_events_cat":[24,23,5,6,7],"class_list":["post-2251","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tag-bcmb","tag-biochemistry-and-molecular-biology","tag-chemistry","tribe_events_cat-bcmb","tribe_events_cat-chemistry","tribe_events_cat-seminars","tribe_events_cat-seniors","tribe_events_cat-stem-success-initiative","cat_bcmb","cat_chemistry","cat_seminars","cat_seniors","cat_stem-success-initiative"],"_links":{"self":[{"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tribe_events\/2251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/users\/95"}],"version-history":[{"count":4,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tribe_events\/2251\/revisions"}],"predecessor-version":[{"id":2463,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tribe_events\/2251\/revisions\/2463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/media\/2458"}],"wp:attachment":[{"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=2251"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tags?post=2251"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/inside.wooster.edu\/chemistry\/wp-json\/wp\/v2\/tribe_events_cat?post=2251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}