{"id":2566,"date":"2026-09-16T15:46:45","date_gmt":"2026-09-16T19:46:45","guid":{"rendered":"https:\/\/inside.wooster.edu\/chemistry\/?post_type=tribe_events&#038;p=2566"},"modified":"2026-09-16T16:16:39","modified_gmt":"2026-09-16T20:16:39","slug":"helen-murray-free-lecture-technical","status":"publish","type":"tribe_events","link":"https:\/\/inside.wooster.edu\/chemistry\/event\/helen-murray-free-lecture-technical\/","title":{"rendered":"Helen Murray Free Lecture &#8211; Technical"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Dr. Catherine Drennan, Professor, Departments of Biology and Chemistry, Howard Hughs Medical Institute Investigator, Massachusetts Institute of Technology <\/h4>\n\n\n<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<p class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\tOctober 22\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t@\t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t11:00 am\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--time\">\n\t\t\t\t\t&#8211;\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--end\">\n\t\t\t\t\t12:00 pm\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__timezone\">EDT<\/span>\n\t\t\t\t\t\t<\/p>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Revealing the secrets of&nbsp;metalloenzymes one snapshot at a time<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Location: Ruth W. Williams Hall of Life Sciences, Room 060<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Abstract:<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"199\" src=\"https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-300x199.jpg\" alt=\"\" class=\"wp-image-2567\" srcset=\"https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-300x200.jpg 300w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-1024x678.jpg 1024w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-768x509.jpg 768w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-1536x1017.jpg 1536w, https:\/\/inside.wooster.edu\/chemistry\/wp-content\/uploads\/sites\/59\/2026\/09\/DRENNAN_Cathy-010-2048x1356.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">How do microbes live on the pollutant carbon monoxide? How do microbes split the triple bond of nitrogen gas? When it comes to performing difficult chemistry, microbes often combine a protein scaffold with a highly reactive metallocofactor; they essentially employ a \u201chired gun.\u201d The Drennan lab combines X-ray crystallography and cryo-electron microscopy with other biophysical methods to reveal the secrets behind metalloenzyme chemistry. In this seminar, Drennan will present her lab\u2019s structural studies of ribonucleotide reductases (RNRs). RNRs use metallocofactors to generate radical species, enabling the conversion of ribonucleotides (the building blocks of RNA) to deoxyribonucleotides (the building blocks of DNA). These enzymes are chemotherapeutic targets and proposed antibacterial targets. Here, Drennan will describe how her lab has used biophysical methods to reveal RNR\u2019s secrets.<\/p>\n\n\n<div  class=\"tribe-block tribe-block__event-price\" >\n\t\t<\/div>\n\n\n\n\n<div  class=\"tribe-block tribe-block__venue tribe-clearfix\" >\n\t\n\t\t\n\t<\/div>\n\n\n\n\n\t<div  class=\"tribe-block tribe-block__events-link\" >\n\t\t<div class=\"tribe-events tribe-common\">\n\t\t\t<div class=\"tribe-events-c-subscribe-dropdown__container\">\n\t\t\t\t<div class=\"tribe-events-c-subscribe-dropdown\">\n\t\t\t\t\t<div class=\"tribe-common-c-btn-border tribe-events-c-subscribe-dropdown__button\">\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--cal-export tribe-events-c-subscribe-dropdown__export-icon\" \taria-hidden=\"true\"\n\tviewBox=\"0 0 23 17\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M.128.896V16.13c0 .211.145.383.323.383h15.354c.179 0 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tribe-events-c-subscribe-dropdown__list-item--gcal\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"https:\/\/www.google.com\/calendar\/event?action=TEMPLATE&#038;dates=20261022T110000\/20261022T120000&#038;text=Helen%20Murray%20Free%20Lecture%20%26%238211%3B%20Technical&#038;details=%3Ch4+class%3D%22wp-block-heading%22%3EDr.+Catherine+Drennan%2C+Professor%2C+Departments+of+Biology+and+Chemistry%2C+Howard+Hughs+Medical+Institute+Investigator%2C+Massachusetts+Institute+of+Technology+%3C%2Fh4%3E%3Ch3+class%3D%22wp-block-heading%22%3ERevealing+the+secrets+of%26nbsp%3Bmetalloenzymes+one+snapshot+at+a+time%3C%2Fh3%3E%3Cp%3ELocation%3A+Ruth+W.+Williams+Hall+of+Life+Sciences%2C+Room+060%3C%2Fp%3E+%3Ch5+class%3D%22wp-block-heading%22%3EAbstract%3A%3C%2Fh5%3E%3Cfigure+class%3D%22wp-block-image+alignright+size-medium%22%3E%3Cimg+src%3D%22https%3A%2F%2Finside.wooster.edu%2Fchemistry%2Fwp-content%2Fuploads%2Fsites%2F59%2F2026%2F09%2FDRENNAN_Cathy-010-300x199.jpg%22+alt%3D%22%22+class%3D%22wp-image-2567%22+%2F%3E%3C%2Ffigure%3E%3Cp%3EHow+do+microbes+live+on+the+pollutant+carbon+monoxide%3F+How+do+microbes+split+the+triple+bond+of+nitrogen+gas%3F+When+it+comes+to+performing+difficult+chemistry%2C+microbes+often+combine+a+protein+scaffold+with+a+highly+reactive+metallocofactor%3B+they+essentially+employ+a+%E2%80%9Chired+gun.%E2%80%9D+The+Drennan+lab+combines+X-ray+crystallography+and+cryo-electron+microscopy+wit%3C%2Fp%3E+%28View+Full+event+Description+Here%3A+https%3A%2F%2Finside.wooster.edu%2Fchemistry%2Fevent%2Fhelen-murray-free-lecture-technical%2F%29&#038;trp=false&#038;ctz=America\/New_York&#038;sprop=website:https:\/\/inside.wooster.edu\/chemistry\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener 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W. 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