Professor James West, Biochemistry & Molecular Biology
Project Description
Cells are constantly exposed to harmful molecules (e.g., oxidizing agents like hydrogen peroxide) that damage biological macromolecules, including DNA and proteins. A variety of enzymes mitigate the negative effects of oxidants, including a family of peroxidases called peroxiredoxins. Baker’s yeast that lack the peroxiredoxin Tsa1 exhibit elevated mutation rates. The goal of this project is to determine whether Tsa1 is a general suppressor of mutations in other yeast strains that exhibit increased mutation rates. Students will learn fundamental microbiology, molecular biology, and cell biology techniques as part of this semester-long study.
Prerequisite Classes/Skills Required
Enrollment in or prior completion of CHEM 112 and BIOL 201
Time expectations
10 hours per week for 11 weeks